干扰素α治疗期间慢性乙型肝炎患者的乙型肝炎表面抗原丢失和动力学：基于医院的真实数据分析，首发论文 -全讯担保网

0
0
浏览
下载

hepatitis b surface antigen loss and kinetic in chronic hepatitis b patients during interferon alpha treatment: a hospital-based real-world data analysis

首发时间：2024-07-22

^{1
2
3}
xin ying (2001-07), female, master student, engaged in research in biomedical statistics.
huang guangyu ⁴ wang yuming ³ ¹
wang kaifa (1972-11), male, professor, engaged in research in the fields of biological mathematics, biomedical statistics, and computational medicine.

1、school of mathematics and statistics, southwest university, chongqing, 400715, china
2、department of infectious diseases, the seventh affiliated hospital, sun yat-sen university, shenzhen 518107, china
3、public health hospital of southwest university, chongqing, 400036, china
4、department of infectious diseases, the seventh affiliated hospital, sun yat - sen university, shenzhen 518107, china

abstract：background: the sustained loss of hepatitis b surface antigen (hbsag) is an important alternative marker for chronic hepatitis b (chb) functional cure, but the predictor for hbsag loss and kinetic of related viral serological patterns in these uncured patients undergone long-term pegylated interferon alpha treatment remains insufficient. methods: retrospective data on chb patients who were admitted to our institutions from may 30, 2018, to january 30, 2023, were collected, which are mostly regular weekly data. a total of 382 patients were enrolled for follow-up analysis, including 232 immune-inactive stage patients and 150 immune-active stage patients, and 95 patients achieved functional cure. binary logistic regression analysis and profile analysis were performed to explore predictive factors for hbsag loss and describe the kinetic patterns of the hbsag continuously positive (cp) patients. results: besides baseline hbsag, age was also the predictor for hbsag loss for immune-inactive stages patients, and the suggested cut-off baseline hbsag were obtained. for cp patients, both two immune stage groups exhibited a gradually decreasing kinetic pattern in hbsag, but there was a reversal kinetic pattern between two immune stage groups in alanine aminotransferase (alt). the difference of hbsag and alt kinetic was mainly reflected in the first 24 weeks after treatment. female and hepatitis b e antigen (hbeag) positive patients had a faster hbsag decline rate than male and hbeag negative patients respectively. conclusions: clinical consequence of hbsag conversion and kinetic are not only correlated with clinical course status, but also related to gender and hbeag grouping (negative/positive).

keywords： chronic hepatitis b interferon therapy multivariable analysis kinetic pattern profile analysis

点击查看论文中文信息

干扰素α治疗期间慢性乙型肝炎患者的乙型肝炎表面抗原丢失和动力学：基于医院的真实数据分析

¹
xin ying (2001-07), female, master student, engaged in research in biomedical statistics.
黄广宇 ² 王宇明 ³ ¹
wang kaifa (1972-11), male, professor, engaged in research in the fields of biological mathematics, biomedical statistics, and computational medicine.

1、西南大学数学与统计学院，重庆，400715
2、中山大学附属第七医院传染病科，深圳，518107
3、西南大学公共卫生医院，重庆，400036

摘要：背景：乙型肝炎表面抗原（hbsag）的持续丢失是慢性乙型肝炎（chb）功能性治愈的重要替代标志物，但在这些接受长期聚乙二醇干扰素α治疗的未治愈患者中，hbsag丢失的预测因素和相关病毒血清学模式的动力学仍然不足。方法：收集2018年5月30日至2023年1月30日期间我院收治的慢性乙型肝炎患者的回顾性数据，这些数据大多为每周定期数据。共招募382名患者进行随访分析，包括232名免疫失活期患者和150名免疫活跃期患者，其中95名患者实现了功能性治愈。进行二元逻辑回归分析和轮廓分析，以探索hbsag丢失的预测因素，并描述hbsag持续阳性（cp）患者的动力学模式。结果：除了基线hbsag外，年龄也是免疫失活期患者hbsag丢失的预测因素，并获得了建议的基线hbsag临界值。对于cp患者，两个免疫阶段组的hbsag均呈逐渐下降的动力学模式，但丙氨酸氨基转移酶（alt）在两个免疫期组之间呈逆转的动力学模式。hbsag和alt动力学的差异主要反映在治疗后的前24周。女性和hbeag阳性患者的hbsag下降速度分别快于男性和hbeag阴性患者。结论：hbsag转化和动力学的临床结果不仅与临床病程状态有关，还与性别和hbeag分组（阴性/阳性）有关。

关键词：慢性乙型肝炎干扰素治疗多变量分析动力学模式轮廓分析

基金：

论文图表：

引用

导出参考文献

xin ying,huang guangyu,wang yuming,et al. hepatitis b surface antigen loss and kinetic in chronic hepatitis b patients during interferon alpha treatment: a hospital-based real-world data analysis[eb/ol]. beijing:sciencepaper online[2024-07-22]. https://www.paper.edu.cn/releasepaper/content/202407-40.

no.****

动态公开评议

共计0人参与

动态评论进行中

全部评论

0/1000

勘误表

干扰素α治疗期间慢性乙型肝炎患者的乙型肝炎表面抗原丢失和动力学：基于医院的真实数据分析

论文编号	202407-40
论文题目	干扰素α治疗期间慢性乙型肝炎患者的乙型肝炎表面抗原丢失和动力学：基于医院的真实数据分析
文献类型
收录期刊	上传封面中文期刊英文期刊期刊名称（中文）期刊名称（英文）年，卷（）上传封面中文专著英文专著书名（中文）书名（英文）出版地出版社出版年上传封面中文译著英文译著书名（中文）书名（英文）出版地出版社出版年上传封面中文论文集英文论文集编者.论文集名称（中文） [c]. 出版地出版社出版年， - 编者.论文集名称（英文） [c]. 出版地出版社出版年，- 上传封面中文文献英文文献期刊名称（中文）期刊名称（英文）日期-- 在线地址http:// 上传封面中文文献英文文献文题（中文）文题（英文）出版地出版社,出版日期-- 上传封面中文文献英文文献文题（中文）文题（英文）出版地出版社,出版日期--
英文作者写法：中外文作者均姓前名后，姓大写，名的第一个字母大写，姓全称写出，名可只写第一个字母，其后不加实心圆点“.”, 作者之间用逗号“，”分隔，最后为实心圆点“.”, 示例1：原姓名写法：albert einstein,编入参考文献时写法：einstein a. 示例2：原姓名写法：李时珍；编入参考文献时写法：li s z. 示例3：yelland r l,jones s c,easton k s,et al.